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QUICK ANSWER
"Que lo que" is a form of "que lo que", a phrase which is often translated as "that what". "De lo que" is a phrase which is often translated as "of what". Learn more about the difference between "que lo que" and "de lo que" below.
que lo que(
keh
 
loh
 
keh
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. that what
Miguel dice que lo que hace es asunto suyo y que nosotros no debemos meternos.Miguel says that what he does is none of our business and that we shouldn't interfere.
b. what
Yo creo que lo que necesito son unas vacaciones.I think what I need is a vacation.
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de lo que(
deh
 
loh
 
keh
)
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. of what
Gran parte de lo que dice el libro es información que está disponible en Internet.Much of what the book says is information you can find on the Internet.
b. which
Estudié italiano, de lo que no me arrepiento.I studied Italian, which I don't regret.
c. than
Esto es más de lo que yo esperaba.This is more than I expected.
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